Fairlie, W. Douglas: search on Z-Library

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1

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

Czabotar, Peter E., Westphal, Dana, Dewson, Grant, Ma, Stephen, Hockings, Colin, Fairlie, W. Douglas, Lee, Erinna F., Yao, Shenggen, Robin, Adeline Y., Smith, Brian J., Huang, David C.S., Kluck, Ruth

Journal:

Year:

2013

Language:

english

File:

PDF, 1.93 MB

english, 2013

2

Mcl-1 and Bcl-xL sequestration of Bak confers differential resistance to BH3-only proteins

Hockings, Colin, Alsop, Amber E., Fennell, Stephanie C., Lee, Erinna F., Fairlie, W. Douglas, Dewson, Grant, Kluck, Ruth M.

Journal:

Cell Death & Differentiation

Year:

2018

Language:

english

File:

PDF, 3.91 MB

english, 2018

3

The role of BCL-2 family proteins and therapeutic potential of BH3-mimetics in malignant pleural mesothelioma

Arulananda, Surein, Lee, Erinna F, Fairlie, W Douglas, John, Thomas

Journal:

Expert Review of Anticancer Therapy

Year:

2020

File:

PDF, 1.05 MB

2020

4

Quinazoline Sulfonamides as Dual Binders of the Proteins B-Cell Lymphoma 2 and B-Cell Lymphoma Extra Long with Potent Proapoptotic Cell-Based Activity

Sleebs, Brad E., Czabotar, Peter E., Fairbrother, Wayne J., Fairlie, W. Douglas, Flygare, John A., Huang, David C. S., Kersten, Wilhelmus J. A., Koehler, Michael F. T., Lessene, Guillaume, Lowes, Kym,

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.81 MB

english, 2011

5

Discovery of Potent and Selective Benzothiazole Hydrazone Inhibitors of Bcl-X L

Sleebs, Brad E., Kersten, Wilhemus J. A., Kulasegaram, Sanji, Nikolakopoulos, George, Hatzis, Effie, Moss, Rebecca M., Parisot, John P., Yang, Hong, Czabotar, Peter E., Fairlie, W. Douglas, Lee, Erinn

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.94 MB

english, 2013

6

BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux

Reljic, Boris, Conos, Stephanie, Lee, Erinna F., Garnier, Jean-Marc, Dong, Li, Lessene, Guillaume, Fairlie, W. Douglas, Vaux, David L., Lindqvist, Lisa M.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.85 MB

english, 2016

7

Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2

FAIRLIE, W. Douglas, SOUZA, David De, NICOLA, Nicos A., BACA, Manuel

Journal:

Biochemical Journal

Year:

2003

Language:

english

File:

PDF, 192 KB

english, 2003

8

A preliminary assessment of oral monepantelâs tolerability and pharmacokinetics in individuals with treatment-refractory solid tumors

Mislang, Anna, Mollard, Richard, Tapia Rico, Gonzalo, Fairlie, W. Douglas, Lee, Erinna F., Harris, Tiffany J., Aston, Roger, Brown, Michael P.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2020

File:

PDF, 589 KB

2020

9

Expression of growth differentiation factor-15/ macrophage inhibitory cytokine-1 (GDF-15/MIC-1) in the perinatal, adult, and injured rat brain

Andreas Schober, Martina Böttner, Jens Strelau, Ralf Kinscherf, Gabriel A. Bonaterra, Martin Barth, Lothar Schilling, W. Douglas Fairlie, Samuel N. Breit, Klaus Unsicker

Journal:

The Journal of Comparative Neurology

Year:

2001

Language:

english

File:

PDF, 1.70 MB

english, 2001

10

Expression of a TGF-β superfamily protein, macrophage inhibitory cytokine-1, in the yeast Pichia pastoris

W.Douglas Fairlie, Hong-Ping Zhang, Peter K. Brown, Patricia K. Russell, Asne R. Bauskin, Samuel N. Breit

Journal:

Year:

2000

Language:

english

File:

PDF, 299 KB

english, 2000

11

Apoptosis in schistosomes: toward novel targets for the treatment of schistosomiasis

Lee, Erinna F., Young, Neil D., Lim, Nicholas T.Y., Gasser, Robin B., Fairlie, W. Douglas

Journal:

Trends in Parasitology

Year:

2014

Language:

english

File:

PDF, 872 KB

english, 2014

12

Epitope Mapping of the Transforming Growth Factor-β Superfamily Protein, Macrophage Inhibitory Cytokine-1 (MIC-1): Identification of at Least Five Distinct Epitope Specificities †

Fairlie, W. Douglas, Russell, Patricia K., Wu, Wan M., Moore, Anthony G., Zhang, Hong-Ping, Brown, Peter K., Bauskin, Asne R., Breit, Samuel N.

Journal:

Year:

2001

Language:

english

File:

PDF, 569 KB

english, 2001

13

The disulphide bond structure of thyroid-stimulating hormone β -subunit

FAIRLIE, W. Douglas, STANTON, Peter G., HEARN, Milton T. W.

Journal:

Biochemical Journal

Year:

1996

Language:

english

File:

PDF, 645 KB

english, 1996

14

Evaluation of Diverse α/β-Backbone Patterns for Functional α-Helix Mimicry: Analogues of the Bim BH3 Domain

Boersma, Melissa D., Haase, Holly S., Peterson-Kaufman, Kimberly J., Lee, Erinna F., Clarke, Oliver B., Colman, Peter M., Smith, Brian J., Horne, W. Seth, Fairlie, W. Douglas, Gellman, Samuel H.

Journal:

Journal of the American Chemical Society

Year:

2012

Language:

english

File:

PDF, 4.45 MB

english, 2012

15

(α/β+α)-Peptide Antagonists of BH3 Domain/Bcl-x L Recognition: Toward General Strategies for Foldamer-Based Inhibition of Protein−Protein Interactions

Sadowsky, Jack D., Fairlie, W. Douglas, Hadley, Erik B., Lee, Hee-Seung, Umezawa, Naoki, Nikolovska-Coleska, Zaneta, Wang, Shaomeng, Huang, David C. S., Tomita, York, Gellman, Samuel H.

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 737 KB

english, 2007

16

A Family of Leukemia Inhibitory Factor-Binding Peptides that Can Act as Antagonists When Conjugated to Poly(ethylene glycol) †

Fairlie, W. Douglas, Uboldi, Alessandro D., Hemmings, George J., Smith, Brian J., Martin, Helene M., Morgan, Phillip O., Baca, Manuel

Journal:

Year:

2003

Language:

english

File:

PDF, 253 KB

english, 2003

17

Cover Picture: Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design (ChemBioChem 13/2011)

Dr. Erinna F. Lee, Assoc. Prof. Brian J. Smith, Dr. W. Seth Horne, Kelsey N. Mayer, Marco Evangelista, Prof. Peter M. Colman, Prof. Samuel H. Gellman, Dr. W. Douglas Fairlie

Journal:

Year:

2011

Language:

english

File:

PDF, 978 KB

english, 2011

18

Cycloadditions of Isobenzofuran to a Constrained Template Bearing Neighboring Dienophiles

Martin J. Stoermer, Douglas N. Butler, Ronald N. Warrener, K. D. V. Weerasuria, David P. Fairlie

Journal:

Chemistry - A European Journal

Year:

2003

Language:

english

File:

PDF, 116 KB

english, 2003

19

A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak

Marc Kvansakul, Mark F. van Delft, Erinna F. Lee, Jacqueline M. Gulbis, W. Douglas Fairlie, David C.S. Huang, Peter M. Colman

Journal:

Year:

2007

Language:

english

File:

PDF, 1.14 MB

english, 2007

20

Simple cis-epoxide-based inhibitors of HIV-1 protease

Andrew D Abell, Deborah A Hoult, Douglas A Bergman, David P Fairlie

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 167 KB

english, 1997

21

Crystal Structure of a BCL-W Domain-Swapped Dimer: Implications for the Function of BCL-2 Family Proteins

Erinna F. Lee, Grant Dewson, Brian J. Smith, Marco Evangelista, Anne Pettikiriarachchi, Con Dogovski, Matthew A. Perugini, Peter M. Colman, W. Douglas Fairlie

Journal:

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

22

The BECN1 N-terminal domain is intrinsically disordered

Lee, Erinna F., Perugini, Matthew A., Pettikiriarachchi, Anne, Evangelista, Marco, Keizer, David W., Yao, Shenggen, Fairlie, W. Douglas

Journal:

Year:

2016

Language:

english

File:

PDF, 1.76 MB

english, 2016

23

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

Erinna F. Lee, Jack D. Sadowsky, Brian J. Smith, Peter E. Czabotar, Kimberly J. Peterson-Kaufman, Peter M. Colman, Samuel H. Gellman, W. Douglas Fairlie

Journal:

Angewandte Chemie

Year:

2009

Language:

english

File:

PDF, 962 KB

english, 2009

24

Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study

David A Brown, Samuel N Breit, Julie Buring, W Douglas Fairlie, Asne R Bauskin, Tao Liu, Paul M Ridker

Journal:

Year:

2002

Language:

english

File:

PDF, 91 KB

english, 2002

25

Structure-Guided Rational Design of α/β-Peptide Foldamers with High Affinity for BCL-2 Family Prosurvival Proteins

Smith, Brian J., Lee, Erinna F., Checco, James W., Evangelista, Marco, Gellman, Samuel H., Fairlie, W. Douglas

Journal:

Year:

2013

Language:

english

File:

PDF, 1.24 MB

english, 2013

26

Screening Procedure for Pichia pastoris Clones Containing Multiple Copy Gene Inserts

Fairlie, W. Douglas, Russell, Patricia K., Zhang, Hong Ping, Breit, Samuel N.

Journal:

Year:

1999

Language:

english

File:

PDF, 33 KB

english, 1999

27

Structural Insights into the Protease-like Antigen Plasmodium falciparum SERA5 and Its Noncanonical Active-Site Serine

Anthony N. Hodder, Robyn L. Malby, Oliver B. Clarke, W. Douglas Fairlie, Peter M. Colman, Brendan S. Crabb, Brian J. Smith

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 1.75 MB

english, 2009

28

STRUCTURAL BIOLOGY OF THE INTRINSIC CELL DEATH PATHWAY: WHAT DO WE KNOW AND WHAT IS MISSING?

Lee, Erinna F., Fairlie, W. Douglas

Journal:

Computational and Structural Biotechnology Journal

Year:

2012

Language:

english

File:

PDF, 3.53 MB

english, 2012

29

Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design

Dr. Erinna F. Lee, Assoc. Prof. Brian J. Smith, Dr. W. Seth Horne, Kelsey N. Mayer, Marco Evangelista, Prof. Peter M. Colman, Prof. Samuel H. Gellman, Dr. W. Douglas Fairlie

Journal:

Year:

2011

Language:

english

File:

PDF, 783 KB

english, 2011

30

Trans-Pacific transport of Saharan dust to western North America: A case study

McKendry, Ian G., Strawbridge, Kevin B., O'Neill, Norman T., Macdonald, Anne Marie, Liu, Peter S. K., Leaitch, W. Richard, Anlauf, Kurt G., Jaegle, Lyatt, Fairlie, T. Duncan, Westphal, Douglas L.

Journal:

Journal of Geophysical Research

Year:

2007

Language:

english

File:

PDF, 1.43 MB

english, 2007

31

The Structural Biology of Bcl-xL

Lee, Erinna F., Fairlie, W. Douglas

Journal:

International Journal of Molecular Sciences

Year:

2019

Language:

english

File:

PDF, 2.53 MB

english, 2019

32

[International Review of Cell and Molecular Biology] Cell Death Regulation in Health and Disease - Part B Volume 352 || Crosstalk between apoptosis and autophagy signaling pathways

Fairlie, W. Douglas

Year:

2020

File:

PDF, 1.69 MB

2020

33

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

Erinna F. Lee, Jack D. Sadowsky, Brian J. Smith, Peter E. Czabotar, Kimberly J. Peterson-Kaufman, Peter M. Colman, Samuel H. Gellman, W. Douglas Fairlie

Journal:

Angewandte Chemie International Edition

Year:

2009

Language:

english

File:

PDF, 962 KB

english, 2009

34

A fusion protein system for the recombinant production of short disulfide-containing peptides

W Douglas Fairlie, Alessandro D Uboldi, David P De Souza, George J Hemmings, Nicos A Nicola, Manuel Baca

Journal:

Protein Expression and Purification

Year:

2002

Language:

english

File:

PDF, 195 KB

english, 2002

35

Peptide inhibitors of the malaria surface protein, apical membrane antigen 1: Identification of key binding residues

Erinna F. Lee, Shenggen Yao, Jennifer K. Sabo, W. Douglas Fairlie, Rachel A. Stevenson, Karen S. Harris, Robin F. Anders, Michael Foley, Raymond S. Norton

Journal:

Year:

2011

Language:

english

File:

PDF, 574 KB

english, 2011

36

Delineation of Tyrosine-Containing Epitopes within the β Subunit of Bovine Thyrotropin

W. Douglas Fairlie, Peter G. Stanton, Milton T. W. Hearn

Journal:

Year:

1995

Language:

english

File:

PDF, 978 KB

english, 1995

37

Structure of the BH3 Domains from the p53-Inducible BH3-Only Proteins Noxa and Puma in Complex with Mcl-1

Catherine L. Day, Callum Smits, F. Cindy Fan, Erinna F. Lee, W. Douglas Fairlie, Mark G. Hinds

Journal:

Journal of Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.62 MB

english, 2008

38

Repurposing apoptosis-inducing cancer drugs to treat schistosomiasis

Lee, Erinna F, Fairlie, Walter Douglas

Journal:

Future Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.39 MB

english, 2015

39

Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells

Carrington, Emma M., Zhang, Jian-Guo, Sutherland, Robyn M., Vikstrom, Ingela B., Brady, Jamie L., Soo, Priscilla, Vremec, David, Allison, Cody, Lee, Erinna F., Fairlie, W. Douglas, Bouillet, Philippe,

Journal:

Proceedings of the National Academy of Sciences

Year:

2015

Language:

english

File:

PDF, 2.11 MB

english, 2015

40

Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1

Albertoni, Michele, Shaw, Phillip H, Nozaki, Michimasa, Godard, Sophie, Tenan, Mirna, Hamou, Marie-France, Fairlie, Douglas W, Breit, Samuel N, Paralkar, Vishwas M, de Tribolet, Nicolas

Journal:

Year:

2002

Language:

english

File:

PDF, 308 KB

english, 2002

41

Conformational Selection of Inhibitors and Substrates by Proteolytic Enzymes: Implications for Drug Design and Polypeptide Processing

Fairlie, David P., Tyndall, Joel D. A., Reid, Robert C., Wong, Allan K., Abbenante, Giovanni, Scanlon, Martin J., March, Darren R., Bergman, Douglas A., Chai, Christina L. L., Burkett, Brendan A.

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 423 KB

english, 2000

42

Characterization of the conformational preference and dynamics of the intrinsically disordered N-terminal region of beclin 1 by NMR spectroscopy

Yao, Shenggen, Lee, Erinna F., Pettikiriarachchi, Anne, Evangelista, Marco, Keizer, David W., Fairlie, W. Douglas

Journal:

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

Year:

2016

Language:

english

File:

PDF, 1.65 MB

english, 2016

43

The propeptide of macrophage inhibitory cytokine (MIC-1), a TGF-β superfamily member, acts as a quality control determinant for correctly folded MIC-1

Bauskin, Asne R., Zhang, Hong-Ping, Fairlie, W.Douglas, He, Xiao Yan, Russell, Patricia K., Moore, Anthony G., Brown, David A., Stanley, Keith K., Breit, Samuel N.

Journal:

The EMBO Journal

Year:

2000

Language:

english

File:

PDF, 460 KB

english, 2000

44

Membrane-bound Fas ligand only is essential for Fas-induced apoptosis

O’ Reilly, Lorraine A., Tai, Lin, Lee, Lily, Kruse, Elizabeth A., Grabow, Stephanie, Fairlie, W. Douglas, Haynes, Nicole M., Tarlinton, David M., Zhang, Jian-Guo, Belz, Gabrielle T.

Journal:

Year:

2009

Language:

english

File:

PDF, 794 KB

english, 2009

45

Contribution of Specific Disulphide Bonds to Two Epitopes of Thyrotropin β-Subunit Associated with Receptor Recognition

W. Douglas Fairlie, Peter G. Stanton, Milton T. W. Hearn

Journal:

Year:

1996

Language:

english

File:

PDF, 820 KB

english, 1996

46

Substrate-Based Cyclic Peptidomimetics of Phe-Ile-Val That Inhibit HIV-1 Protease Using a Novel Enzyme-Binding Mode

March, Darren R., Abbenante, Giovanni, Bergman, Douglas A., Brinkworth, Ross I., Wickramasinghe, Wasantha, Begun, Jake, Martin, Jennifer L., Fairlie, David P.

Journal:

Journal of the American Chemical Society

Year:

1996

Language:

english

File:

PDF, 236 KB

english, 1996

47

Residue-Based Preorganization of BH3-Derived α/β-Peptides: Modulating Affinity, Selectivity and Proteolytic Susceptibility in α-Helix Mimics

Peterson-Kaufman, Kimberly J., Haase, Holly S., Boersma, Melissa D., Lee, Erinna F., Fairlie, W. Douglas, Gellman, Samuel H.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 2.11 MB

english, 2015

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